Principal Investigators

  

Michel

  

  

  

  

Prof. Michel Simonneau - Scientific Coordinator
INSERM U894 - Centre for Psychiatry and Neuroscience
2 ter Rue d'Alésia
75014 Paris
FRANCE

Email

  

Expertise - Work on ageing-related diseases is one of the core activities of Prof. Michel Simonneau's group. Over the last 5 years the group has focused on developing state of the art technologies for functional genomics of genes involved in multifactorial psychiatric diseases. This work has led to a series of papers on synaptic dysfunction in animal models of human disease including the European LOAD-GWAS papers on gene associated to LOAD.


Role in AgedBrainSYSBIO -
Michel Simonneau is AgedBrainSYSBIO's coordinator and is involved in WPs 1, 2, 3 and 4. The group will be participation in curating data (WP1); focus on providing novel quantitative description of protein-protein interactions of LOAD-GWAS gene products and other key proteins identified from modeling, using novel models from patient-derived neurons and mouse transgenic lines (WP2); manipulate patient-derived iPScs using BAC constructs and rare variants from LOAD-GWAS patients to be analyzed and tested in relevant models (WP3); and finally make the final constructs of intrabodies using an aav strategy (WP4)


Relevant publications

  • Kvajo M, et al. (2011) Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice. Proc Natl Acad Sci U S A. 108(49):E1349-58.
  • Hollingworth P, et al. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 43(5):429-35.
  • Loe-Mie Y, et al. (2010) SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. Hum Mol Genet. 19:2841-57.
  • Lambert JC, et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 41(10):1094-9
  • Lepagnol?Bestel AM et al. (2008) SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry. 13(4):385?97.

Team Members
Cécile Viollet (PhD, scientist) – Expertise: Interneuron
Yann Loe-Mie (PhD, postdoc)

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BroeckhovenChristineVan

 

   

  

Prof. Christine van Broeckhoven
Director Department of Molecular Genetics
University of Antwerp – CDE
Universiteitsplein 1
B-2610 Antwerp
BELGIUM
Email

 


Expertise
- The Neurodegenerative Brain Diseases group of the VIB Department of Molecular Genetics (VIB-DMG) headed by Prof. Christine van Broeckhoven, University of Antwerp, is a national and internationally recognized excellence center for neurodegenerative brain diseases research. The group has near 30 years of experience in molecular genetics of Alzheimer and related neurodegenerative brain diseases, playing a crucial role in the elucidation of the genetic underpinnings of these diseases, both for the Mendelian and the genetically complex forms. A strong network with clinicians at the national level ensures follow-up of patients, and a large biobank allows translation of genetic findings to ex vivo patient material. The biobank of the VIB-DMG holds biomaterials of an extended research cohort of (amongst others) 1314 Alzheimer patients and 1223 control individuals of Flanders-Belgian origin.

 

Role in AgedBrainSYSBIO - WP2: Quantification of gene products in patient biomaterials. WP3: collection of skin samples for culture of fibroblast cell lines, which will be used for the generation of iPSC. Identification of genetic variants underlying GWAS signals, that can be studied further in light of the proposal
 

Relevant publications

  • Bettens K, et al. (2012) Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. Mol Neurodegener. 7(1):3.
  • Brouwers N. et al. (2011) Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Mol Psychiatry doi:10.1038/mp.2011.24
  • Hollingworth P, et al. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 43(5):429-35.
  • Lambert JC, et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 41(10):1094-9
  • Harold D, et al. (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet. 41(10):1088-93

Team Members
Kristel Sleegers (PhD, scientist) – Expertise: Genetic Neuroepidemiology
Karolien Bettens (PhD, postdoc) – Expertise: Molecular Genetics, Alzheimer

  

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jean-charles-lambert

  

  

Dr. Jean-Charles Lambert
UMR 744 – Public health and molecular epidemiology of aging related diseases
Institut Pasteur de Lille
1 rue du Pr. Calmette BP 245
59019 Lille cedex
FRANCE
Email

 

Expertise - Dr. Jean-Charles Lambert is recognised expert in the field of Alzheimer’s Disease genetics. The team is mainly interests in to characterize the AD genetic components but also to improve our understanding of how these determinants modify the AD pathophysiological process. Since 2006 the team has published more than 68 peer reviewed articles and registered three patents.


Role in AgedBrainSYSBIO
-  Jean-Charles Lambert will participate to the efforts in WP3 manipulating pathways using human iPSC-derived neurons, mouse and drosophila models.

 

Relevant publications

  • Lambert JC et al. (2012) Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer’s disease. Mol Psychiatry, in press.
  • Hollingworth P,* Harold D*, Sims R*, Gerrish A,* Lambert JC,* et al. (2011) Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 43:429-35. * equally contributed to this work
  • Lambert JC, Amouyel P. (2010) Deciphering genetic susceptibility to frontotemporal lobar dementia. Nat Genet. 42:189-90.
  • Lambert J-C. et al. (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet. 41:1094-9.
  • Dreses-Werringloer U. et al. (2008) A polymorphism in CALHM1 Ca2+ homeostasis, A? level and Alzheimer’s disease risk. Cell 27;133:1149-61.

Team Members
Bart Dermaut (PhD, senior scientist) – Expertise: Genetics and Drosophilae
Pierre Dourlen (PhD, postdoc) – Expertise : Genetics and Drosophilae

  

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Dr. Yann Herault
Institut CERBM/ICS – Institut Clinique de Souris
1 rue Laurent Fries,
67404 Illkirch
FRANCE
Email

 


Expertise – Dr. Yann Herault is an expert in mouse genetics and director of the Mouse Clinic Institute (ICS), an infrastructure of excellence, which provides services for the scientific community. The ICS has a long tradition of collaboration with both academic community and pharmaceutical industries with more than a 1000 of mouse models generated in the last 9 years, and with an international recognition The  ICS is equipped with integrated facilities for genetics, cellular and molecular biology, and notably for creation and characterization of genetically engineered mouse models.
 

Role in AgedBrainSYSBIO - WP2: Identification of interacting protein partners from Late-Onset Alzheimer Disease Genome-Wide Association Studies (LOAD-GWAS) gene products. WP3: Manipulating pathways using human iPSC-derived neurons, mouse and drosophila models.
 

Relevant publications

  • Danglot L et al. (2012). Absence of TI-VAMP/Vamp7 Leads to Increased Anxiety in Mice. J. Neuroscience, in press.
  • Braudeau J.  et al. (2011) A non convulsant ?5-selective GABAA receptor inverse agonist restores cognitive deficits in a mouse model of Down syndrome. J Psychopharmacol. 25, 1030-1042.
  • Birling M.-C. et al. (2011) Highly-efficient, fluorescent, locus directed Cre and flpo deleter mice on a pure C57BL/6N genetic background. Genesis. 10:1002.
  • Liu M. et al. (2010) PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. J. Lipid Res.  51, 2611-8.
  • Lopes Pereira, P et al. (2009) A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic coded of Down syndrome Hum. Mol. Genet. 18, 4756-4769

Team Members
Guillaume Pavlovic (PhD, senior scientist) – Expertise: Generation and validation of genetically mouse models

  

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James 2 

 

  

Prof. James Adjaye - WP3 leader
Director Institute for Stem Cell Research
Medical Faculty Heinrich-Heine-Universität Düsseldorf
Moorenstraße 5,
40225 Düsseldorf
GERMANY
Email

 


Expertise – Prof. James Adjaye hasextensive experience in the derivation and characterization of iPSCs from dermal fibroblast from healthy individuals but also Alzheimer’s disease patients, differentiation of iPSCs into neuronal cells and analysis of aged related transcriptional changes in mouse tissues, human dermal fibroblasts and iPSCs derived from dermal fibroblasts of aged individuals. Since May 2012 Prof Adjaye is the Director of the newly established Institute for Stem Cell Research and Regenerative Medicine (ISRM) at the Heinrich Heine University, Düsseldorf, Germany.


Role in AdedBrainSYSBIO
– James Adjaye will lead the efforts in WP3. The tasks include; (1) Genome wide transcriptome comparison of dermal fibroblasts derived from Alzheimer’s patients and aged matched (40yrs and 80 yrs) healthy controls; (2) Derivation and characterization of patient-specific iPSCs to enable further differentiation of human neurons subtypes: principal cortical neurons and inter-neurons and(3) Manipulating neurons from patient-specific iPSCs.

 

Relevant publications 

  • Prigione A et al. (2011). Human iPSCsharborhomoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining hESC-like metabolic reprogramming.Stem Cells9:1338-48
  • Prigione A et al. (2011). Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in both young and aged donor-derived iPS cells despite chromosomal aberrations.PLoS One.6(11):e27352

  • Prigione A et al. (2010). The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells. Stem Cells 4:721-733

  • Lukas Chavez et al. (2010) Computational analysis of genome-wide DNA-methylation alterations during the differentiation of human embryonic stem cells along the endodermal lineage. Genome Research, 20(10):1441-50.

  • Brink TC.et al.  (2009). Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of ageing. Biogerontology. 10(5):549-64.

Team Members
Friederike Schröter (PhD, Postdoc) – Expertise: StemCell Technology, Neurobiology
Heiko Fuchs (PhD, Postdoc) – Expertise: StemCell Technology, Neurobiology
Silke Wehrmeyer (BTA, Labmanager) - Elizabeth Socha (BTA)
Both technicians will help by the reprogramming and cultivation of the iPS cells.

  

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TAL

   

Prof. Tal Pupko 
Department of Cell Research and Immunology,
George S. Wise Faculty of Life Sciences,
Tel Aviv University
Tel Aviv 69978
ISRAEL
Email

 

Expertise – Prof. Tal Pupko’s main research interests focus on fields of Molecular Evolution and Bioinformatics and notably on studying the evolutionary selective forces shaping genes and genomes and the in-silico predictions of these forces using probabilistic evolutionary models. Tal Pupko has published several papers on alignment methods and alignment reliability (The program Guidance), developed a webserver for predicting functional regions in proteins (Consurf), and a web server to detect positively selected sites (Selecton).
 

Role in AgedBrainSYSBIO – The group will be in involved in the following tasks in WP1: (1) Establish multiple sequence alignments in high throughput manner; (2) To filter unreliable alignment regions; (3) To construct phylogenetic trees from all these alignments; (4) To search signature of selection (accelerated evolution or positive selection) in the lineage leading to human. From those genes that are relevant to ageing and show patterns of positive selection in the lineage leading to human, candidate will be chosen for detailed characterization.
 

Relevant publications

  • Privman, E, et al. (2012) Improving the performance of positive selection inference by filtering unreliable alignment regions. Mol. Biol. Evol. 29(1):1-5.
  • Rubinstein, N.D. et al. 2011. Evolutionary models accounting for layers of selection in protein coding genes and their impact on the inference of positive selection . Mol. Biol. Evol. 28(12):3297-3308.
  • Penn, O et al. (2010) GUIDANCE: a web server for assessing alignment confidence scores. Nucleic Acids Research. 38(Web Server issue):W23-W28.
  • Loe-Mie1, Y et al. (2010). SMARCA2 and other genome-wide supported schizophrenia-associated genes: regulation by REST/NRSF, network organization and primate-specific evolution. Human Molecular Genetics 19(14):2841-2857.
  • Gelfman, S et al. (2012) Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons. Genome Res. 22(1):35-50.

Team Members
Michael Dunaevsky (MsC student)

  

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jean christophe

  

Dr. Jean-Christophe Rain - WP2 leader
HYBRIGENICS Services
3-5 Impasse Reille
75014 Paris
FRANCE
Email

 

Expertise – Dr Jean-Christophe Rain is Director Industrial Operation and Technology Development, at HYBRIGENICS Services. He is the company founder and expert in yeast two hybrid technology with 34 peer review publications in this field and 10 patents. During TrioH (FP6 LSHB-CT-2003-503480), HYBRIGENICS conducted a vast interaction mapping in the HIV field. This work lead to many scientific publications but also to the identification, characterization and validation of a new anti-HIV target now used for drug discovery program in the biotech and pharma industry..

 

Role in AgedBrainSYSBIO – Jean-Christophe Rain is leading WP2 and responsible for the following tasks: (i) Screening of in human and drosophila library using bait protein selected for their relevance in brain ageing. Construction of libraries of specific neurons and interneurons subtypes. (ii) Display of the interacting data through an optimized display software. (iii) Curation relative to interaction data in the knowledge database. (iv) Modelling process relative interaction network and domain-domain interactions and interaction localization.

  

Relevant publications

  • Criollo et al. (2011) Inhibition of autophagy by TAB2 and TAB3. EMBO J. 30, 4908-4920.
  • Rigou et al. (2009) The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation.  EMBO J, 28, 1576–1588.
  • Vielemeyer O., et al. (2010) Characterization of single chain antibody targets through yeast two hybrid. BMC Biotechnol.  10:59.
  • Camargo LM, et al.(2007)  Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry. 12(1):74-86.

Team Members
Vincent Collura (Dr, scientist) – Expertise: Bioinfomatics
Valérie Hindié (Dr, scientist) - Expertise: Biochemistry, yeast two hybrid

 

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Jaak

  

  

 

Prof. Jaak Vilo - WP1 leader
QURETEC Ltd
Ülikooli 6A
51003 Tartu
ESTONIA
Email

 

Expertise – Jaak Vilo has a long-standing expertise in bioinformatics data mining. He was pioneering the gene expression data analysis and database setup at the European Bioinformatics Institute.Prof. Vilo manages a bioinformatics research group BIIT (http://biit.cs.ut.ee ) and is well known expert in the field of gene expression and bioinformatics data mining areas. The ENFIN project (2006-2011) developed systems biology approaches for network reconstruction and simulations, especially in stem cells. This expertise will be brought over to the ageing and related pathologies investigations.
 

Role in the project  - QURETEC will lead WP1 and develop the omics data management and analysis platform. In collaboration with other WP-s like WP3 a consortium data analysis pipeline and database interface will be developed allowing project partners seamlessly interact with these data over the web interfaces.
 

Relevant publications

  • Kolde, R. et al. (2012) Robust Rank Aggregation for gene list integration and meta-analysis. Bioinformatics  doi:10.1093/bioinformatics/btr709
  • Adler, P et al. (2009) Mining for coexpression across hundreds of datasets using novel rank aggregation and visualisation methods. Genome Biology 10:R139. doi:10.1186/gb-2009-10-12-r139
  • Reimand, J et al. (2011). g:Profiler—a web server for functional interpretation of gene lists (2011 update). Nucleic Acids Research 39 Suppl 2:W307-15.
  • Jung M. et al. (2010) A Data Integration Approach to Mapping OCT4 Gene Regulatory Networks Operative in Embryonic Stem Cells and Embryonal Carcinoma Cells. PLoS ONE 5(5): e10709. doi:10.1371/journal.pone.0010709
  • Billon N. et al. (2010) Comprehensive transcriptome analysis of mouse embryonic stem cell adipogenesis unravels new processes of adipocyte development. Genome Biol. 11(8):R80. Epub 2010 Aug 3.

Team Members
Elena Nikolaeva (PhD, postdoc) - Expertise:
Hedi Peterson  (PhD, postdoc) - Expertise:

  

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harald site

  

  

  

Dr. Harald Kranz
GENEBRIDGES GmbH
Im Neuenheimer Feld 584
69120 Heidelberg
GERMANY
Email

 

Expertise – Dr. Harald Kranz has extensive experience in DNA engineering. The scientific service group headed by Dr. Kranz at GENEBRIDGES has provided academic institutes with DNA engineering services for nearly ten years. Services include the generation of tailored constructs for animal or cell culture models by Red/ET recombination.
 

Role in AgedBrainSYSBIO – GENEBRIDGES is involved in WP2 and WP3 with the following main tasks: In preparation for immunoprecipitation experiments, GENEBRIDGES will modify key genes identified in LOAD-GWAS by adding tap-tags for the derivation of BAC transgenic and knock-in mouse lines. A further objective is the creation of humanized mouse alleles, through the generation of targeting constructs in which mouse exons have been replaced by their human counterparts. Insertion of point mutations into the targeting constructs will allow analysis of the relevance/effect of SNPs in disease-related alleles.
 

Relevant publications

  • Murga, M. et al. (2009) A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated ageing. Nature Genetics 41,  891- 898.
  • Noll, S.  et al. (2009) Site-directed mutagenesis of multi-copy- number plasmids: Red/ET recombination and unique restriction site elimination. BioTechniques 46, 527-533.
  • Poser, I.  et al. (2008) BAC transgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods 5, 409–415.
  • Wang, J.  et al. (2006) An improved recombineering approach by adding recA to ? red recombination. Mol. Biotechnology 32, 43-53.

Team Members
Jan Reyelt   (PhD, scientist) - Expertise: DNA Engineering

  

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PHOTO

  

  

  


Dr. Gerard Griffioen- WP4 leader

reMYND nv
Gaston Geenslaan 1
3001 Heverlee
BELGIUM
Email

 

Expertise – reMYND CRO has 10 years of experience as a partner in preclinical research activities to test experimental treatments against AD in animal models. The PI involved in the project Dr. Dick Terwel, holds a PhD in Neuroscience and has a vast background in preclinical AD research. Prior to joining reMYND, he has been working as post-doctoral researcher at the Department of Human Genetics of Leuven University and as Senior Scientist and Lecturer at the Department of Neurology of University Clinics Bonn.

 

Role in AgedBrainSYSBIO – reMYND is leading WP4 activities. Main tasks include: (i) Testing of intrabodies targeting protein-protein interaction of GWAS products in screens recapitulating noxious properties of pathological protein aggregates involving toxicity and functional read-outs. (ii) Testing of subset of intrabodies in mice involving determination of intrabody distribution and levels of expression  in mouse brain and functional changes at the synapse. (iii) In depth investigation of efficacy of intrabodies on pathology, synaptic markers and behaviour in Tau.P30L- and APPLd mice.
 

Relevant patents
WO 2007/140933 Methods and tools for the screening of factors affecting protein misfolding.
WO 2007/090617 Thiadiazole derivatives for the treatment of neuro-degenerative diseases
WO 2008/061781 Thiadiazole derivatives for the treatment of neuro-degenerative diseases
WO 2009/019295 Phenyl- and benzylthiazolypiperazine derivatives for the treatment of neuro-degenerative diseases
WO 2010/142801 Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases 

  

Team Members

 

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Henning site small

  

Dr. Henning Hermjakob - WP5 leader
Proteomics Services
EMBL-EBI
Wellcome-Trust Genome Campus, Hinxton
Cambridge, CB10 1SD
UNITED KINGDOM
Email

 

Expertise – Dr. Henning Hermjakob is expert in the development and implementation of data standards for network and pathway data. The group has a long experience in encoding and annotating pathways and models. It has maintained reference computing resources for sharing these datasets during many years, including standard formats, annotation schemes and databases and is in charge of worldwide reference data resources in proteomics (PRIDE), interactomics (IntAct), pathways (Reactome) and models (BioModels Database).
 

Role in AgedBrainSYSBIO WP1:The group will focus on extracting from public resources existing interaction networks, pathways and models, in a form suitable for the tasks of the other partners. It will also encode the interaction networks, pathways and models generated by the project in standard formats, suitable for sharing with the community through AgedBrainSYSBIO database and public repositories. Dr. Hermjakob will also be strongly involved in dissemination and training activities and lead WP5.
 

Relevant publications

  • Griss J, et al. PRIDE Cluster: building aconsensus of proteomics data. Nat Methods. 2013 Feb;10(2):95-6.
  • Orchard S, et al. Protein interaction datacuration: the International Molecular Exchange (IMEx) consortium. Nat Methods.2012 Apr;9(4):345-50.
  • Croft D et al. (2011) Reactome: a database of reactions, pathways and biological processes. Nucleic Acids Res,  39(Database issue): D691-D697.
  • Li C et al. (2010) BioModels Database, enhanced curated and annotated resource of published quantitative kinetic models. BMC SystBiol, 4:92
  • Hermjakob H et al. (2004) The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol., 22: 177-183.
  • Hucka et al. (2003) The Systems Biology Markup Language (SBML): A Medium for Representation and Exchange of Biochemical Network Models. Bioinformatics19: 524-531.

Team Members
Camille Laibe  (PhD, BioModels database coordinator) - Expertise: Database development, Systems biology data representation standards

  

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xenarios

  

  

  

  

  

Dr. Ioannis Xenarios
Swiss-Prot group - CMU
1, rue Michel Servet,
1211 Geneva 4
SWITZERLAND
Email

 

Expertise – Dr. Ioannis Xenarios is the Director of Vital-IT. He has extensive experience in computational methodologies in the area of proteomics, microarray, genetics and dynamical systems modeling.
 

Role in AgedBrainSYSBIOWP1:Together Vital-IT and SwissProt will contribute to AgedBrainSYSBIO by providing expertise, tools and methodology for integration of data sets coming different technologies and expertise for the creation of manually curated regulatory networks and in simulating in silico tools the dynamical behaviours of the curated regulatory network. Furthermore, the group will perform large epistasis analysis of LOAD-GWAS data taking advantage of developed algorithm in quantitative phenotypic analysis. Ioannis Xenarios will also be involved in dissemination and training activities in WP5.
 

Relevant publications 

  • Kapur K, et al. (2011) Comparison of Strategies to Detect Epistasis from eQTL Data.PLoS One.  6(12):e28415.  Epub 2011 Dec 19.
  • Garg A, et al. (2012)  Implicit methods for qualitative modelling of gene regulatory networks.Methods Mol. Biol. 786:397-443.
  • Liechti R, et al. (2010) EuroDia: a beta-cell gene expression resource.Database (Oxford). 2010 Oct 12;2010:baq024. Print 2010.
  • Schüpbach T, et al. (2010) .FastEpistasis: a high performance computing solution for quantitative trait epistasis.Bioinformatics 26(11):1468-9. Epub 2010 Apr 7.
  • Garg A, et al. (2008) Synchronous versus asynchronous modelling of gene regulatory networks.Bioinformatics 24(17):1917-25. Epub 2008 Jul 9.

Team Members
Jerôme Dauvillier (Dr, Bioinformatics Scientist) - Expertise: Neurobiology, GWAS
Thierry Schuepbach (Dr Computer Scientist) - Expertise: High performance computing, epistasis
Brigitte Boeckmann (Dr. Bioinformatics Scientist) - Expertise:Phylogeny, evolutionnaryprocesses

  

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le novere nicolas

 

  

    

Dr. Nicolas Le Novère
The Babraham Institute
Babraham Campus Cambridge
Cambridgeshire CB22 3AT
UNITED KINGDOM
Email

 

Expertise – Dr. Nicolas Le Novère is a leading figure in the field of pathway and model sharing, being a creator of SBML, SBGN and developer of BioPAX. The group created BioModels Database, the world leading database of systems biology models, now part of the EBI Proteomics Services. During its period at the EBI, the research of the group focused on modelling neuronal signalling, using various approaches and granularity. Dr. Le Novère is a partner of SynSys, an FP7 project dedicated to the systems biology of synaptic function.
 

Role in AgedBrainSYSBIO – WP1 From information existing in public resources and literature, as well as knowledge generated by other partners, the group will reconstruct key pathways involved in neuron ageing and etiology of AD. It will then develop computational models of selected ones, in order to predict perturbations for testing by the other workpackages. The group will advise on encoding and sharing pathways and models generated by the project in standard formats.
 

Relevant publications

  • Demir E et al (2010) BioPAX – A Community Standard for Pathway Data Sharing. Nat Biotechnol, 28: 935-942
  • Li C et al. (2010) BioModels Database, enhanced curated and annotated resource of published quantitative kinetic models. BMC Syst Biol, 4:92
  • Stefan M.I. et al. (2008) An allosteric model of calmodulin explains differential activation of PP2B and CaMKII. Proc Natl Acad Sci USA, 105: 10768-10773.
  • Fernandez E. et al. (2006) DARPP-32 is a robust integrator of dopamine and glutamate signals. PLoS Comput Biol , 2(12): e176.
  • Hucka et al. The Systems Biology Markup Language (SBML): A Medium for Representation and Exchange of Biochemical Network Models. Bioinformatics (2003), 19: 524-531.

Team Members
Lu Li (PhD, post-doc) - Expertise: calcium signalling, reaction-diffusion models
Martina Froehlich (PhD, post-doc) - Expertise: signalling pathways, biochemical models
Simone Zorzan (PhD, visitor) - Expertise: protein-protein interaction dynamics, neuronal regeneration

 

 

 

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Dr. Christiane Dascher-Nadel - Project Manager 
Inserm Transfert SA
Department of European and International Affairs
18 avenue Mozart
13276 Marseille Cedex 09
FRANCE
Email

  

Expertise – Dr. Christiane Dascher-Nadel has extensive experience in both academic and industrial R&D research and has been active in the field of EC project management for the past nine years. She is heading a management team within Inserm Transfert’s European and International Affairs department mainly focused on research projects related to stem cells and biotherapy.
 

Role in AgedBrainSYSBIO - Christiane Dascher-Nadel is leading WP6 – Project Management and Coordination. She will ensure a professional driving of the project, provide the partners with adequate communication tools and implement an appropriate strategy for knowledge management. In WP5 she will coordinate dissemination and communication activities.
 

Team Members
Dahlia Tsakiropoulos  - Expertise: Degree in law, expert in business and contract law
Sandrine Graff - Expertise: Assistant European projects

 

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ESTHER

 

Dr. Esther Steidl
Co-Founder, Head Of The Multi-Electrode Array Laboratory
NeuroService

Domaine de Saint Hilaire
595 rue Pierre Berthier – CS 30531
13593 Aix en Provence cedex 03
FRANCE
Email

 

Expertise – Esther-Marie is Co-Founder and Head of the MEA Laboratory at Neuroservice. Esther-Marie has managed Neuroservice’s MEA Laboratory since its inception. Over an 11-year experience with this technique, she has developed and validated dozens of pharmacological and screening assays. Working in close collaboration with scientists from many big pharmaceutical and biotech companies, she has gained a unique experience in drug testing on acute slices with MEA. Esther trained in Biochemistry and earned a Master’s Degree in cellular engineering from the University of Nancy, France.

Role in AgedBrainSYSBIO - Neuroservice is involved in the WP4. It will consist in determining synaptic plasticity properties at 3 different hippocampal synapses and cortical synapses of Wild Type (WT) and Transgenic (Tg) mice.

  

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Last update on 2017-07-22

AgedBrainSYSBIO has received funding from the European Union’s Seventh Framework Programme for research,
technological development and demonstration under grant agreement No 305299
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